Table 2. Absolute concentrations of metabolites (in mmol/L) in bilateral posterior cingulate gyrus and dorsal thalamus.
| Metabolites | NPSLE (N = 22) |
non-NPSLE (N = 21) |
HC (N = 20) |
F | p | |||
|---|---|---|---|---|---|---|---|---|
| Mean ± SD | Adjusted Mean | Mean ± SD | Adjusted Mean | Mean ± SD | Adjusted Mean | |||
| RPCG |
||||||||
| NAA | 9.323 ± 1.174 | 9.325 | 9.467 ± 2.512 | 9.469 | 10.826 ± 0.980 | 10.823 | 4.585 | 0.014 |
| Cho | 1.258 ± 0.300 | 1.257 | 1.196 ± 0.333 | 1.237 | 1.438 ± 0.142 | 1.425 | 2.153 | 0.158 |
| MI | 5.445 ± 2.075 | 5.485 | 5.147 ± 1.617 | 5.145 | 5.660 ± 1.134 | 5.621 | 0.360 | 0.699 |
| Glx | 14.940 ± 3.385 | 14.957 | 14.267 ± 3.810 | 14.215 | 16.417 ± 3.531 | 16.447 | 1.654 | 0.201 |
| tCr | 6.203 ± 1.131 | 6.192 | 6.121 ± 1.598 | 6.112 | 7.297 ± 0.799 | 7.318 | 5.947 | 0.005 |
| RDT | ||||||||
| NAA | 7.152 ± 1.280 | 7.206 | 7.818 ± 0.941 | 7.823 | 8.411 ± 0.736 | 8.350 | 5.020 | 0.010 |
| Cho | 2.053 ± 0.495 | 2.050 | 2.107 ± 0.328 | 2.107 | 2.145 ± 0.293 | 2.148 | 0.260 | 0.772 |
| MI | 5.600 ± 1.418 | 5.524 | 5.673 ± 1.279 | 5.668 | 5.563 ± 1.467 | 5.653 | 0.057 | 0.944 |
| Glx | 12.816 ± 2.752 | 12.421 | 14.365 ± 2.217 | 14.336 | 15.402 ± 2.375 | 15.827 | 7.672 | 0.001 |
| tCr | 6.388 ± 1.211 | 6.316 | 6.995 ± 1.150 | 6.989 | 7.342 ± 0.824 | 7.425 | 4.239 | 0.019 |
| LPCG | ||||||||
| NAA | 9.757 ± 1.564 | 9.762 | 11.013 ± 1.616 | 11.006 | 11.219 ± 1.056 | 11.218 | 4.668 | 0.013 |
| Cho | 1.520 ± 0.291 | 1.441 | 1.562 ± 0.317 | 1.573 | 1.647 ± 0.221 | 1.723 | 4.483 | 0.016 |
| MI | 5.924 ± 1.569 | 5.838 | 5.510 ± 0.927 | 5.520 | 5.795 ± 1.372 | 5.886 | 0.438 | 0.648 |
| Glx | 13.870 ± 3.425 | 13.607 | 14.176 ± 3.467 | 14.197 | 16.047 ± 2.331 | 16.329 | 3.154 | 0.050 |
| tCr | 6.563 ± 1.288 | 6.301 | 6.901 ± 0.893 | 6.924 | 7.435 ± 0.857 | 7.700 | 7.769 | 0.001 |
| LDT | ||||||||
| NAA | 9.045 ± 0.944 | 9.071 | 9.736 ± 1.221 | 9.737 | 10.067 ± 1.053 | 10.036 | 3.383 | 0.041 |
| Cho | 1.901 ± 0.291 | 1.877 | 2.034 ± 0.237 | 2.034 | 1.975 ± 0.230 | 2.000 | 2.041 | 0.139 |
| MI | 5.290 ± 1.559 | 5.172 | 5.494 ± 1.175 | 5.492 | 4.466 ± 1.222 | 4.597 | 2.087 | 0.133 |
| Glx | 12.725 ± 2.949 | 12.550 | 12.438 ± 2.851 | 12.439 | 12.242 ± 1.943 | 12.443 | 0.010 | 0.990 |
| tCr | 6.488 ± 0.796 | 6.451 | 7.001 ± 0.866 | 7.007 | 6.922 ± 0.678 | 6.955 | 2.959 | 0.060 |
Abbreviations: NPSLE = neuropsychiatric systemic lupus erythematosus; HC = healthy control; PCG = posterior cingulate gyrus; DT = dorsal thalamus; NAA = N-acetylaspartate; Cho = choline; tCr = total creatine; MI = myoinositol; Glx = glutamine + glutamate.