Table 3. Association between Ocular factors and Primary Open-Angle Glaucoma.
| Ocular Factors | POAG, n = 273 | |||
|---|---|---|---|---|
| Model 1* | Model 2** | |||
| OR (95% CI) | P value | OR (95% CI) | P value | |
| IOP: | ||||
| Per mmHg increase | 1.15 (1.10 to 1.20) | <0.001 | 1.16 (1.11 to 1.21) | <0.001 |
| ≥ 20 mmHg (vs <20 mmHg) | 3.13 (2.31 to 4.24) | <0.001 | 3.26 (2.38 to 4.47) | <0.001 |
| Axial length (AL): | ||||
| Per mm increase | 1.22 (1.13 to 1.31) | <0.001 | 1.26 (1.17 to 1.36) | <0.001 |
| AL <23.5 mm | 1.00 (reference) | - | 1.00 (reference) | - |
| 23.5 mm ≤ AL <24.5 mm | 1.63 (1.18 to 2.26) | 0.003 | 1.68 (1.20 to 2.34) | 0.002 |
| 24.5 mm ≤ AL <25.5 mm | 2.05 (1.35 to 3.13) | 0.001 | 1.98 (1.30 to 3.03) | <0.001 |
| AL ≥ 25.5 mm | 3.14 (1.94 to 5.06) | <0.001 | 3.30 (2.04 to 5.33) | <0.001 |
| Refractive status (SE):† | ||||
| Per negative dioptre | 1.07 (1.02 to 1.12) | 0.003 | 1.07 (1.02 to 1.12) | 0.004 |
| Non-myope (>−0.50D) | 1.00 (reference) | - | 1.00 (reference) | - |
| Low-myope (−0.5D to −3.0D) | 1.03 (0.77 to 1.38) | 0.834 | 1.08 (0.78 to 1.51) | 0.638 |
| Moderate-to-high myope (<−3.00D) | 2.36 (1.65 to 3.37) | <0.001 | 2.11 (1.44 to 3.09) | <0.001 |
POAG = Primary Open-Angle Glaucoma; IOP = Intraocular pressure; SE = Spherical Equivalent; CCT = Central corneal thickness; OR = Odds ratio; CI = Confidence interval.
*Adjusted for age, gender, ethnicity.
**Adjusted for age, gender, ethnicity, IOP, CCT and axial length.
†Eyes with history of cataract surgery were excluded. Axial length was removed in this model because of collinearity with spherical equivalent.