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. 2016 Jan 14;6:19275. doi: 10.1038/srep19275

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Copyright © 2016, Macmillan Publishers Limited

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Animals sacrificed 6 mo. after hepatocyte transplantation and maintained on tamoxifen diet. (A,C) H&E staining of a representative section of repopulated rat liver at orig. mag. 4× and 60×, respectively. (B,D) serial section of the same liver region stained for DPPIV at orig. mag. 4× and 60×, respectively. On both H & E and DPPIV staining, liver tissue post lenti TTR-YapERT2 transduced hepatocyte transplantation was totally normal and transplanted cells and their progeny were incorporated into a totally normal liver structure, without evidence for dedifferentiation, dysplasia or malignant transformation.