Figure 4. Overexpression of Cdo1 inhibits Wnt signaling.
(A) Overexpression of Cdo1 repressed luciferase activity. (B) Overexpression of Cdo1 inhibited mRNA expression of Wnt target genes, Axin2 and Dkk1, induced by treatment with Wnt3a. (C) Overexpression of Cdo1 inhibited mRNA expression of osteogenic transcription factors, Runx2 and Dlx5, in mBMSCs treated with Wnt3a (100 ng/ml) for 4 hours. *p < 0.05.