Figure 4. Comparison between the transcriptomic alterations of the endothelium in the STOX1 model and HUVECs exposed to preeclamptic plasma.

HUVECs were exposed for 72 hours to mild or severe PE plasma and their transcriptome analyzed using human expression microarrays. DEGs identified in HUVECs exposed to mild or severe preeclampsia plasma were used to build networks (mild-PE-Ntw and severe_PE-Ntw)which were compared to the preeclamptic mice EC network, using the bioinformatics tool NeAT²⁴. The figure shows the common genes and interactions resulting from the intersection between the severe-PE-Ntw and the preeclamptic mice EC network. Enrichment analysis detects sets of genes involved in inflammation, extra-cellular matrix, TGFβ cascades and coagulation processes. IL6, IL1B and ITGBI figure among the principal hub genes in the network.