Figure 3. Mechanisms of aggregation.

Schemes of the microscopic steps that make up the reaction network in the four different models (model 1, 2, 3 and 4) tested in the kinetic analyses. The free fitting parameters for each model are given as well, the reaction orders are given in brackets, as they are either fitted (in models 1b, 2b, 3b and 4b) or fixed to their value found in the case of wt Aβ42 at pH8 (in models 1a, 2a, 3a and 4a). Further details given in Fig S3.