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. 2016 Jan 25;11(1):e0147269. doi: 10.1371/journal.pone.0147269

Fig 4. Histological analysis finds evidence of increased fibrosis in the BACHD hearts in response to the adrenoreceptor challenge.

Fig 4

Examples of Masson’s Trichrome (A) stained heart sections from WT and BACHD mice treated with saline or ISO. Quantification of fibrosis by measurement of the optical density of blue staining confirmed increased fibrosis in the ISO-treated BACHD animals (B). Comparison of heart dimensions from H & E sections (C) and morphological measurements of WT and BACHD (D) mice indicated that the heart weight/body weight ratio was higher in both groups following ISO treatment. However, there were no significant differences between the genotypes. * P < 0.05 between genotypes; # P<0.05 vs. saline within a genotype.