Table 3. Echocardiographic parameters from BACHD and WT animals (6 mo) following chronic administration of isoproterenol (0.97 mg/day for 30 days).
Echo Measurements | WT (n = 10) | BACHD (n = 8) | t-test |
---|---|---|---|
Lv Mass (mg) | 73 ± 3 | 94 ± 11 | T = -1.8, P = 0.08 |
ESD (mm) | 2.9 ± 0.1 | 3.4 ± 0.3 | T = -1.9, P = 0.06 |
EDD (mm) | 4.2 ± 0.1 | 4.4 ± 0.3 | T = -0.7, P = 0.45 |
PWT (mm) | 0.51 ± 0.01 | 0.55 ± 0.02 | T = -1.5, P = 0.14 |
Lv EF | 67 ± 3 | 56 ± 3* | T = 2.59, P = 0.01 |
* P<0.05 significant difference between genotypes.