Table 5. Histological measurements in WT and BACHD mice (6 mo) following 12 wks of isoproterenol challenge.
| Histological Measurements | WT | BACHD | Two-way Repeated Measures ANOVA | ||||
|---|---|---|---|---|---|---|---|
| Drug | Saline (n = 4) | ISO (n = 5) | Saline (n = 4) | ISO (n = 5) | Genotype | Drug | Interaction |
| Lv Diameter (mm) | 3.4 ± 0.2 | 4.1 ± 0.1* | 2.2 ± 0.2‡ | 3.5 ± 0.3† | F1 = 13.1, P<0.001 | F1 = 16.7, P<0.001 | F1 = 1.26, P = 0.269 |
| Lv Area (mm2) | 7.12 ± 0.94 | 10.84 ± 0.59* | 3.21 ± 0.48‡ | 8.40 ± 1.65† | F1 = 8.49, P = 0.006 | F1 = 16.7, P<0.001 | F1 = 0.46, P = 0.503 |
| Lv Thickness (mm) | 0.79 ± 0.09 | 0.67 ± 0.04 | 1.33 ± 0.11‡ | 1.13 ± 0.17‡ | F1 = 18.1, P<0.001 | F1 = 1.96, P = 0.171 | F1 = 0.12, P = 0.733 |
| Septal Thickness (mm) | 0.70 ± 0.08 | 0.68 ± 0.02 | 1.26 ± 0.08‡ | 1.06 ± 0.15‡ | F1 = 21.6, P<0.001 | F1 = 1.16, P = 0.289 | F1 = 0.76, P = 0.380 |
| Rv area (mm2) | 3.8 ± 0.5 | 3.1 ± 0.3 | 5.0 ± 0.6 | 3.7 ± 0.6 | F1 = 3.47, P = 0.083 | F1 = 3.58, P = 0.079 | F1 = 0.28, P = 0.603 |
| Rv thickness (mm) | 0.39 ± 0.02 | 0.42 ± 0.04 | 0.47 ± 0.05 | 0.41 ± 0.03 | F1 = 1.19, P = 0.284 | F1 = 0.20, P = 0.657 | F1 = 1.35, P = 0.255 |
* P<0.05 within WT, significant difference vs saline,
† P<0.05 within HD, significant difference vs saline,
‡ P<0.05 significant difference between genotypes under the same condition.
Rv = Right ventricle.