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. 2016 Jan 25;11(1):e0147269. doi: 10.1371/journal.pone.0147269

Table 8. List of apoptosis related genes altered in BACHD ventricles compared to WT at the same age.

Probe Accession Enzyme name Symbol Fold Change P value
Young Hearts (3 mo)
ILMN_1225608 NM_008679 Nuclear Receptor Coactivator 3 Ncoa3 -0.179 0.00107
ILMN_3079866 NM_009845.1 Cluster of Differentiation-22 Cd22 -0.155 0.00138
ILMN_3035162 NM_133220.2 Serum/Glucocorticoid Regulated Kinase 3 Sgk3 -0.178 0.00145
ILMN_2943477 NM_025304.3 Leucine Carboxyl Methyl Transferase 1 Lcmt1 -0.163 0.00157
ILMN_2793522 NM_013869.3 Tumor Necrosis Factor Receptor Superfamily, Member 19 Tnfrsf19 -0.198 0.00251
ILMN_1247125 NM_025923.2 Fanconi Anemia, Complementation Group L Fancl -0.174 0.00262
ILMN_2776952 NM_009687 Apurinic/Apyrimidinic Endonuclease 1 Apex1 -0.145 0.00294
ILMN_2675776 NM_023879 Retinitis Pigmentosa GTPase Regulator Interacting Protein 1 Rpgrip1 -0.117 0.00406
ILMN_1236489 NM_029410.1 BCL2-like 12 Bcl2l12 -0.213 0.00435
ILMN_2866752 NM_007530.2 B-cell Receptor-associated Protein 29 Bcap29 -0.149 0.00435
ILMN_1234453 NM_016809.2 RNA Binding Motif Protein 3 (Rbm3) Rbm3 -0.553 0.00466
ILMN_2749737 NM_031843.2 Dipeptidylpeptidase 7 Dpp7 0.207 0.00038
ILMN_2726837 NM_008726.2 Natriuretic Peptide Precursor Type B Nppb 0.466 0.00083
ILMN_1232240 NM_026238.2 Nuclear Prelamin A Recognition Factor-like Narfl 0.173 0.00106
ILMN_1248293 NM_009534.1 Yes-associated Protein 1 Yap1 0.29 0.00236
ILMN_2621752 NM_012057.1 Nterferon Regulatory Factor 5 Irf5 0.182 0.00261
ILMN_2829594 NM_010479.2 Heat Shock Protein 1A Hspa1a 1.42 0.00284
ILMN_2510383 NM_033042.2 Tumor Necrosis Factor Receptor Superfamily, Member 25 Tnfrsf25 0.259 0.00307
ILMN_2735350 NM_011819.1 Growth Differentiation Factor 15 Gdf15 0.376 0.00337
ILMN_2611812 NM_027395 Membrane Attached Signal Protein 1 (Basp1) Basp1 0.152 0.00426
Aged Hearts (15 mo)
ILMN_2886828 NM_011243.1 Retinoic Acid Receptor, Beta Rarb -0.371 0.00194
ILMN_2968211 NM_010706.1 Lectin, Galactose Binding, Soluble 4 Lgals4 -0.366 0.00222
ILMN_1229161 NM_007932 Endoglin Eng -0.356 0.00258
ILMN_1235374 NM_026172.3 2,4-Dienoyl CoA Reductase 1 Decr1 -0.311 0.0029
ILMN_2657175 NM_007585.2 Annexin A2 Anxa2 -0.292 0.00482
ILMN_2623591 NM_009685.1 Amyloid Beta (A4) Precursor Protein-binding, Family B, Member 1 Apbb1 -0.283 0.0013
ILMN_2724942 NM_008968.2 Prostaglandin I2 (prostacyclin) Synthase Ptgis -0.27 0.00382
ILMN_2594714 NM_011809.2 E26 Avian Leukemia Oncogene 2 Ets2 -0.255 0.00291
ILMN_2613904 NM_024441.1 Heat Shock Protein 2 Hspb2 -0.241 0.00456
ILMN_2592093 NM_018854.3 Intraflagellar Transport Protein 20 Ift20 -0.235 0.00103
ILMN_2724386 NM_177613.2 Cell Division Cycle 34 Cdc34 -0.222 0.0034
ILMN_2991107 NM_029342.3 Non-Homologous End-Joining Factor 1 Nhej1 -0.218 0.00051
ILMN_2589651 NM_008486.1 Alanine Aminopeptidase Anpep -0.204 0.00129
ILMN_2480180 NM_016862 Vesicle Transport Through Interaction with t-SNAREs 1A Vti1a -0.186 0.00377
ILMN_2678336 NM_007795.1 Cardiotrophin 1 Ctf1 -0.185 0.00316
ILMN_1223738 NM_011034.2 Peroxiredoxin 1 Prdx1 -0.168 0.00383
ILMN_2726271 NM_133205.1 Arrestin 3, retinal Arr3 -0.164 0.00463
ILMN_1228796 NM_023179.2 ATPase, H+ Transporting, Lysosomal V1 Subunit G2 Atp6v1g2 -0.162 0.00392
ILMN_2598703 NM_010509.1 Interferon (alpha and beta) Receptor 2 Ifnar2 -0.148 0.00378
ILMN_1224846 NM_153785.1 Cyclin-dependent Kinase-like 3 Cdkl3 0.138 0.00139
ILMN_2722864 NM_010875 Neural Cell Adhesion Molecule 1 Ncam1 0.148 0.00304
ILMN_1228881 NM_013523.2 Follicle Stimulating Hormone Receptor Fshr 0.155 0.00105
ILMN_1216788 NM_172773.1 Solute Carrier Family 17 Slc17a5 0.163 0.00124
ILMN_1215951 NM_138315.1 Microtubule Associated Monoxygenase, Calponin and LIM Domain Containing 1 Mical1 0.176 0.00473
ILMN_2667369 NM_022305.2 Beta-1,4-Galactosyl Transferase 1 B4galt1 0.186 0.00159
ILMN_2594450 NM_008960 Phosphatase and Tensin Homolog Pten 0.188 0.00329
ILMN_2680549 NM_029094.1 Phosphatidylinositol-4,5-bisphosphate 3-kinase Catalytic Subunit Beta Isoform Pik3cb 0.197 0.00383
ILMN_3097726 NM_178846.1 Guanine Nucleotide Binding Protein-like 3 Gnl3 0.203 0.00303
ILMN_2661125 NM_019791.1 Melanoma Antigen, Family D, 1 Maged1 0.205 0.00082
ILMN_1229318 NM_172665.1 Pyruvate Dehydrogenase Kinase, Isoenzyme 1 Pdk1 0.209 0.00393
ILMN_2840091 NM_011673.2 UDP-glucose Ceramide Glucosyltransferase Ugcg 0.215 0.00459
ILMN_1250213 NM_019464.1 SH3-domain GRB2-like B1 Sh3glb1 0.221 0.00444
ILMN_1220096 NM_028193.1 Belgischer Rundfunk 1 Brf1 0.232 0.00173
ILMN_1235481 NM_021880.1 Protein Kinase, cAMP Dependent Regulatory, Type I, Alpha Prkar1a 0.239 0.00126
ILMN_1259127 NM_026602.1 Breast Carcinoma Amplified Sequence 2 Bcas2 0.297 0.0031
ILMN_1259174 NM_009132.1 Scinderin Scin 0.308 0.00243
ILMN_2727503 NM_008343 Insulin-like Growth Factor Binding Protein 3 Igfbp3 0.314 0.0041
ILMN_1224768 NM_133838 EH-domain Containing 4 Ehd4 0.336 0.00101
ILMN_2676606 NM_181848.3 Optineurin Optn 0.34 0.00175
ILMN_2434472 NM_009413.1 Tumor Protein D52-like 1 Tpd52l1 0.388 0.0024
ILMN_2716567 NM_009761.2 BCL2/Adenovirus E1B Interacting Protein 3-like Bnip3l 0.391 0.00071
ILMN_2728729 NM_011521.1 Syndecan 4 Sdc4 0.444 0.0014
ILMN_1226016 NM_198885.2 Scleraxis Scx 0.458 0.00035
ILMN_2625451 NM_013468.2 Ankyrin Repeat Domain 1 Ankrd1 0.559 0.00391
ILMN_3161547 NM_008725.1 Natriuretic Peptide Type A Nppa 1.316 3.00E-04