Figure 4. sCLU is involved in miR-378-induced cisplatin resistance.

(A) A549/DDP cells were transfected with Mock, miR-378 mimics or sCLU plasmid lacking 3′UTR along with miR-378, MTT assays were used to measure cisplatin sensitivity (*P < 0.05 **P < 0.01). (B) sCLU, pERK1/2, pAKT, Bcl-2, and caspase-3 protein levels were detected by Western blot analysis.