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(A) CD31 staining revealed that sulindac reduced tumor angiogenesis in 4T1 tumor model. Scale bars, 50 μm. (B) Quantification of tumor vessel densities was assessed. *P < 0.05. (C) The level of VEGF and PlGF was evaluated by RT-PCR. Sulindac reduced pro-angiogenic factors VEGF and PlGF. **P < 0.01.
