Figure 7. Merged protein-protein interaction network of the enriched transcription factors from all timepoints (d5, d7, d10, d14), obtained from STRING.

Interactions with a high confidence >0.7 are visualized. Proteins are clustered using the MCL algorithm. Every color represents a cluster. Inter-cluster edges are represented by dashed lines. Non-connected gene nodes are not visualized. We could identify the development of three distinct large node clusters, including retinoic acid nuclear receptors, containing PPARγ and RAR α/β, and two large interconnected cardiac networks centered on either GATA4 or NKX-5.