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. 2016 Jan 18;6:19470. doi: 10.1038/srep19470

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Copyright © 2016, Macmillan Publishers Limited

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NDRG1 promotes M-CSF-induced proliferation and differentiation of hematopoietic stem cells (HSCs)/common myeloid precursors (CMPs), leading to an increase in the population of monocytes/macrophages but not granulocytes. NDRG1 further promotes the terminal differentiation of monocytes/macrophages into M1- and M2-type macrophages, osteoclasts, and monocyte-derived dendritic cells. NDRG1, however, does not play a critical role in the differentiation of mesenchymal stem cells (MSCs) into osteoblasts. Black arrows, NDRG1 is involved; gray arrows, NDRG1 is not involved.