Table 1. Summary of the thermodynamic folding characteristics of mitochondrial pre-mRNAs in their free and editosome-bound RNA folding state.
pre-mRNA |
||||||
---|---|---|---|---|---|---|
RPS12pe | ND3pe | A6pe | CYbme | COIne | ||
In silico | ΔGRNAStructure | −102 | −98 | −98 | −344 | −468 |
ΔGViennaRNA | −103 | −107 | −107 | −336 | −459 | |
RNAfree | ΔGSHAPE | −152 | −137 | −137 | −496 | −823 |
ΔG/nt | −0.45 | −0.37 | −0.34 | −0.41 | −0.48 | |
ΔG/bp | −1.46 | −1.35 | −1.59 | −1.27 | −1.47 | |
r(ntbp/ntss) | 0.62 | 0.57 | 0.47 | 0.64 | 0.66 | |
RNAed.-bound | ΔGSHAPE | −127 | −124 | −113 | −407 | −725 |
ΔG/nt | −0.38 | −0.33 | −0.28 | −0.33 | −0.43 | |
ΔG/bp | −1.39 | −1.23 | −1.62 | −1.09 | −1.39 | |
r(ntbp/ntss) | 0.54 | 0.55 | 0.37 | 0.61 | 0.61 | |
ΔΔG | 25 | 14 | 23 | 89 | 98 | |
ΔΔG/nt | 0.08 | 0.04 | 0.06 | 0.07 | 0.06 | |
ΔΔG/bp | 0.07 | 0.12 | −0.03 | 0.17 | 0.08 | |
Δntbasepaired (%) | −7.7 | −2.7 | −10.1 | −3.1 | −4.5 | |
bp preserved (%) | 84 | 82 | 50 | 55 | 52 |
∆G-values are in kcal/mol. pe: pan-edited, me: marginally edited, ne: never edited.