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. 2016 Jan 18;6:19378. doi: 10.1038/srep19378

Figure 6. I262T modifies the window currents of Kv1.1 and Kv1.4 channels.

Figure 6

Steady-state activation and inactivation curves of “Kv1.1 vs. I262T” (A), “Kv1.1 WT-WT dimer vs. WT-I262T dimer” (B), and “Kv1.4-Kv1.1 WT dimer vs. Kv1.4-Kv1.1 I262T dimer” (C) were assembled from those shown in Figs 1,4 and 5. Kv1.1 inactivation curves are based on Kvβ1.1-mediated fast inactivation, whereas Kv1.4-Kv1.1 inactivation curves concern the inherent fast inactivation of Kv1.4. Solid lines refer to constructs comprising the mutant, whereas dashed lines denote the corresponding WT control. The window current of each indicated construct is defined by the triangular area underneath the overlap of activation and inactivation curves. See Supplementary Table S5 for more details on the parameters of window currents.