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. 2016 Jan 18;6:19288. doi: 10.1038/srep19288

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Copyright © 2016, Macmillan Publishers Limited

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(a) Isorhamnetin specially inhibits the transcriptional activity of PPARγ, but not PPARα (b) and PPARβ (c). IR1, IR2, IR3: 10, 25 and 50 μM of IR. (d) Binding of isorhamnetin and rosiglitazone on PPARγ-LBD in a competitive TR-FRET assay. (e) The structure of the complex of the PPARγ LBD and isorhamnetin by molecular docking. (f) The 2D-interaction map of the complex of the PPARγ LBD and isorhamnetin. IR: isorhamnetin. Data are presented as means ± SEM (n = 3). *P < 0.05, **P < 0.01.