Figure 1. Influence of ONX 0914 on C. albicans-induced production of IL-6, IL-17A, and IFN-γ by murine splenocytes and human PBMCs in vitro.
Culture supernatant levels of IL-6, IL-17A, and IFN-γ were measured by ELISA. (A) Naive murine splenocytes were pulsed with DMSO or 200 nM ONX 0914 for 2 h and cultured in the presence of heat-killed C. albicans yeast for up to 6 days. Data are representative for one out of three independent experiments and expressed as mean +/− SD. (B) Human PBMCs from healthy donors were treated as described in (A) and cultured in the presence of heat-killed C. albicans hyphae for 5 days. Data represent blood samples from three different donors. Data are analyzed by two-way ANOVA with *p < 0.05 and **p < 0.01.