Figure 4. Applicability of the cofactor-interacting protein network.

Schematic representation of three potential applications of the cofactor-interacting protein network. A first path (blue) can be followed in order to identify the proteins, biological pathway(s) (circled in blue in the network) and clinical phenotype(s) or disease that should be modulated by an intervention on the basis of its nutrient composition. A second path (red) following the reverse approach in which cofactor-interacting proteins (circled in red in the network) involved in biological pathway(s) or disease of interest can be mapped onto the network in order to identify the cofactors – and by extension the nutrients – that would need to be targeted by a nutrient-based intervention in order to modify said phenotype(s) of interest. A third path (green) can rely on the network to investigate the potential origins of inter-individual variability in response to a nutritional intervention by investigating genetic variants in cofactor-interacting proteins involved in proteins and pathway(s) (circled in green in the network) linked to clinical markers of interest.