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. 2016 Jan 18;6:19525. doi: 10.1038/srep19525

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Copyright © 2016, Macmillan Publishers Limited

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Survival of embryos infected with S. pneumoniae D39 strain and treated (or not) with different concentrations of auranofin or auranofin-PLGA NPs (n= 24 to 36 embryos per condition) is shown. Controls with DMSO, auranofin, ampicillin alone and loaded into PLGA NPs were also included. Embryos were monitored for survival over a period of 5 days and results were plotted as Kaplan–Meier survival curves. Survival curves were compared with the log-rank (Mantel–Cox) and Gehan–Breslow–Wilcoxon tests (*P < 0.01; **P < 0.001).