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. 2016 Jan 20;6:19526. doi: 10.1038/srep19526

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(A) Amino acid (AA) diversity given as percentage of amino acid mutations (y axis) observed at helix α₁₈ residues 619, 620 and 621 in genotype 1a, 1b, 2 and 3 variants (x axis) from euHCVdb. (B) Detail of PDB structure 1CU1 showing helix α₁₈ residues 619, 620 and 621 and neighboring residue side chains with potential impact for molecular changes in RNA replication in helicase variants.