Table 1. Genotype/subtype-specific sequence diversity.
| Pairwise based diversity | Max Median Min Mean | 0.117 0 0 0.004 | 0.303 0 0 0.038 | 0.172 0 0 0.017 | 0.439 0.051 0 0.067 | |
|---|---|---|---|---|---|---|
| Residue | Wild type | Variant | Genotype/Subtype |
|||
| 1a | 1b | 2 | 3 | |||
| 438 | F | L | – | 1 | – | – |
| 488 | S | T | – | 1 | 1 (2.2%) | – |
| 524 | V | F | – | 2 | – | – |
| I | 2 | – | ||||
| 525 | C | W | – | 2 | – | – |
| H | – | – | 1 (2.2%) | – | ||
| 526 | Q | M | – | 1 | – | – |
| H | 1 | – | – | – | ||
| 527 | D | V | – | 1 | – | – |
| 528 | H | Y | – | 1 | – | – |
| 529 | L | – | – | – | – | – |
| 530 | E (1a, 1b, 2) D (3) | G | 1 | – | – | – |
| E | – | – | – | 2 (6.9%) | ||
| 531 | F | L | – | – | – | 1 (3.5%) |
| 532 | W | S | – | 2 | – | – |
| 534 | G (1a)S (1b, 3) A (2) | G | 1 | 74 (20.6%) | 2 (4.4%) | 1 (3.5%) |
| A | 1 | 1 | – | – | ||
| D | 1 | – | – | |||
| R | – | – | – | 1 (3.5%) | ||
| 619 | I | V | – | 3 | 2 (4.4%) | 7 (24.1%) |
| L | – | – | – | 2 (6.9%) | ||
| N | – | – | – | 1 (3.5%) | ||
| 620 | M (1a, 2, 3)A (1b) | T | – | 4 (1.1%) | 1 (3.5%) | |
| G | – | – | 1 (2.2%) | – | ||
| A | – | – | – | 1 (3.5%) | ||
| K | – | – | – | 1 (3.5%) | ||
| 621 | T (1a, 2) A (1b, 3) | T | 3 (1.4%) | 35 (9.8%) | 1 (3.5%) | |
| 622 | C | S | – | 1 | – | – |
| 623 | M | – | – | – | – | – |
| 624 | S (1a, 1b, 3) Q (2) | A | 1 | 10 (2.8%) | – | 1 (3.5%) |
| W | – | 1 | – | |||
Variants at helicase residues are summarized together with their respective absolute number and relative abundance (in %) from the euHCVdb. Frequencies are only indicated when ≥1%. Column two indicates the wild-type residue (if the wild type residue differs between genotypes, the respective genotype/subtype is given in brackets).