Figure 2. TubA (25 mg/kg) administered at 24 hours after ischemic onset significantly improved functional recovery and reduced brain infarct volume in the middle cerebral artery occlusion (MCAO) model in rats at least three days after ischemia.

Functional deficits were evaluated by Rotarod test (A), neurological deficit score (B), and body tilting test (C). (D) Brain infarction was assessed by TTC staining on Day 3 after MCAO. (E) Quantification of infarct volume. ^###P < 0.001 compared with sham control; *P < 0.05, **P < 0.01 compared with MCAO group; n = 8 per group.