Figure 4. Hierarchical cluster analysis was conducted for all the differentially expressed proteins in the different treatment groups.

SIPI-8294/Oxa, SIPI-8294, Oxa, Ery and Ery/Oxa, as well as the outcome that would be expected if SIPI-8294 and Oxa acted independently (Additive). Each row indicates one treatment group and each column represents one differentially expressed protein (shown in the zoom-in image). The color indicates relative fold changes (up-regulation relative to mean fold change in red, and down-regulation relative to mean fold change in green). The “Additive” group is generated by multiplying the corresponding fold changes of each differentially expressed protein in the SIPI-8294 treatment group and the Oxa treatment group.