Table 1. List of dysregulated metabolites identified in the serum of mice throughout the entire infection process.
| Modes | mz | Name | Rt (min) | 7d* | 14d* | 21d* | Metabolic pathways |
|---|---|---|---|---|---|---|---|
| ESI+ | 104.1072 | Choline | 0.78 | −1.16 | −1.20 | −0.35 | Glycine, serine and threonine metabolism; Glycerophospholipid metabolism; bile secretion |
| 258.1101 | Glycerophosphocholine | 0.81 | −0.95 | −1.54 | −0.78 | Glycerophospholipid metabolism | |
| 118.0863 | Valine | 1.2 | −0.65 | 0.53 | 0.63 | Valine, leucine and isoleucine degradation and biosynthesis | |
| 150.0584 | Methionine | 1.21 | −0.35 | −0.71 | 0.25 | Cysteine and methionine metabolism | |
| 182.0812 | L-Tyrosine | 1.25 | −1.18 | −1.08 | 0.58 | Tyrosine metabolism; Phenylalanine metabolism; Phenylalanine, tyrosine and tryptophan biosynthesis; Thiamine metabolism | |
| 165.0544 | Phenylpyruvic acid | 1.25 | −1.19 | −1.04 | 0.58 | Phenylalanine metabolism; Phenylalanine, tyrosine and tryptophan biosynthesis | |
| 177.1022 | Serotonin | 1.79 | −1.06 | −3.30 | −0.73 | Tryptophan metabolism; bile secretion | |
| 209.092 | Kynurenine | 2.27 | 0.83 | 2.72 | 1.80 | Tryptophan metabolism | |
| 170.0598 | Phosphorylcholine | 4.12 | −1.69 | −0.62 | 0.38 | Glycerophospholipid metabolism | |
| 146.0601 | Spermidine | 4.13 | −1.67 | −0.57 | 0.34 | Not known | |
| 205.0972 | Tryptophan | 4.13 | −1.60 | −0.66 | 0.37 | Phenylalanine, tyrosine and tryptophan biosynthesis | |
| 398.3268 | Trans-Hexadec-2-enoyl carnitine | 10.01 | 0.46 | −1.03 | −0.93 | Not known | |
| 482.3244 | PE (18:0)/PC (15:0) | 10.72 | 0.36 | 1.05 | 0.27 | Not known | |
| 440.3137 | PE (O-16:0)/PC (O-13:0) | 11.51 | −0.66 | −0.98 | 0.65 | Not known | |
| 504.3066 | PE(20:3) | 12.44 | 1.14 | −0.43 | 0.31 | Not known | |
| ESI− | 242.0798 | Cytidine | 0.81 | −0.66 | −0.73 | −0.71 | Pyrimidine metabolism |
| 180.0666 | L-Tyrosine | 1.27 | −1.23 | −0.49 | 0.77 | Tyrosine metabolism | |
| 130.0873 | L-Leucine | 1.42 | −0.51 | 1.14 | 0.79 | Valine, leucine and isoleucine degradation; Valine, leucine and isoleucine biosynthesis | |
| 245.0933 | N-Acetyl-DL-tryptophan | 6.14 | −2.25 | −2.11 | −1.18 | Not known | |
| 508.3408 | 1-heptadecanoyl-sn-glycero-3-phosphocholine | 12.56 | −0.21 | 0.48 | 0.14 | Not known | |
| 303.2328 | Arachidonic Acid | 13.69 | −0.65 | −1.17 | −0.72 | Arachidonic acid metabolism | |
| 305.2488 | Eicosatrienoic acid | 14.1 | −0.60 | −1.14 | −0.49 | Not known |
*indicates Log2 Fold change.