Table 5. Factors associated with structural progression defined by an increase in mSHS >1 within the first 2 years of follow-up with quartiles of DKK-1 serum levels included in the model (multivariate analysis).
| Parameter | Adjusted OR | 95% CI | p-value |
|---|---|---|---|
| DKK-1 level | |||
| Q2 vs Q1 | 1.31 | 0.77–2.23 | 0.95 |
| Q3 vs Q1 | 1.19 | 0.71–2.0 | 0.60 |
| Q4 vs Q1 | 2.05 | 1.21–3.48 | 0.05 |
| Anti-CCP antibodies | 1.68 | 1.13–2.49 | 0.01 |
| Typical erosions | 1.94 | 1.06–3.55 | 0.03 |
| Biologic therapy | 1.86 | 0.98–3.55 | 0.06 |
Q1, <19.2; Q2, 19.2–27.3; Q3, 27.3–34.8, and Q4 >34.8 pmol/L.