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. 2016 Jan 22;6:19817. doi: 10.1038/srep19817

Figure 7. iNOS inhibition improves lymph node uptake in obese mice.

Figure 7

(a) Representative 99mTc heat maps from experimental animals displaying uptake of 99mTc to the popliteal lymph node (yellow circles). (b) Quantification of peak nodal uptake of 99mTc in the popliteal lymph node. Data is represented as a fold change relative to the lean control group (n = 4 animals/group, p < 0.01). (c) Quantification of the rate of uptake of 99mTc to the popliteal lymph node (n = 4 animals/group, p < 0.05). (d) Representative photomicrographs (20x) and quantification of (e) lymphatic vessel density (LYVE-1+ vessels/HPF) in hindlimb sections (n = 5 animals/group with 4–5 HPF/animal, p < 0.05). (f) Quantification of the number of perilymphatic IFN-γ+ cells (p < 0.05). (g) Quantification of the number of perilymphatic pSMAD-3+ cells (p < 0.05).