Table 3. Ectopic lipids before and after exercise in patients with GHD before and after GHRT and in control subjects.
| MRS | GHD (pre-treatment) | GHRT (post-treatment) | CS | |||
|---|---|---|---|---|---|---|
| p (pre-exercise vs. post) | p (pre-exercise vs. post) | p (pre-exercise vs. post) | ||||
| IMCL pre-exercise(mmol/kg wet weight) | 2.9 (n = 8)(2.6, 4.5) | 3.9 (n = 8)(2.5, 5.7) | 3.6 (n = 9)(2.7, 6.2) | |||
| IMCL post-exercise(mmol/kg wet weight) | 2.5 (n = 8)(2.4, 3.8) | p = 0.069 (n=8/8) | 3.4 (n = 8)(1.6, 4.9) | p = 0.036 (n = 8/8) | 3.2 (n = 9)(2.3, 5.2) | p = 0.008 (n = 9/9) |
| ∆ IMCL(% from baseline) | −9.4 (n = 8)(−15.7, −2.9) | −13.5 (n = 8)(−35.0, −3.5) | −15.4 (n = 9)(−27.9, −8.2) | |||
| IHCL pre-exercise(% from total signal) | 2.1 (n = 10)(1.0, 6.9) | 1.9 (n = 9)(1.2, 3.8) | 4.0 (n = 10)(1.5, 23.5) | |||
| IHCL post-exercise(% from total signal) | 2.4 (n = 10)(1.7, 8.0) | p = 0.005 (n = 10/10) | 2.1 (n = 9)(1.4, 4.4) | p = 0.008 n = (9/9) | 4.3 (n = 10)(2.1, 25.2) | p = 0.009(n = 10/10) |
| ∆ IHCL(% from baseline) | 23.2 (n = 10)(5.2, 35.6) | 15.9 (n = 9)(11.4, 28.7) | 11.8 (n = 10)(5.6, 47.1) | |||
Values are median and interquartile range. All comparisons between groups GHD, GHRT, and CS were non-significant.
GHD = patient with growth hormone deficiency; GHRT = patients after growth hormone replacement therapy; CS = control subjects; MRS = magnetic resonance spectroscopy; IMCL = intramyocellular lipids; IHCL = intrahepatocellular lipids; ∆IMCL and ∆IHCL = difference of intramyocellular and intrahepatocellular lipids before and after 2 h exercise at 50–60% VO2max.
Differences between groups and between pre and post were evaluated by a non-parametric paired test (Wilcoxon Ranked Sign Test).