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. 2016 Jan 20;6:19685. doi: 10.1038/srep19685

Figure 4. The suppressive effect of CD5+ B cells on casein-induced allergic (CIA) responses is allergen-specific.

Figure 4

(A) Mesenteric lymph node (MLN) CD5+ B cells from normal, casein, or ovalbumin (OVA)-sensitized donor mice were transferred to recipient mice before induction of CIA. (B) The severity of CIA was evaluated by changes in body temperatures and symptom scores in the recipient mice. (C) Casein-specific IgE and IgG1 antibodies were measured by ELISA. (D) The percentage and number of IL-10-producing CD5+ B cells in MLNs were counted by flow cytometry. Data are mean ± SEM (n = 8). The statistical differences between the Casein and other groups are shown (B). **p < 0.01; *p < 0.05; n.s., not significant.