Figure 5. LPS-induced bladder functional changes in WT, P2X₂^−/− and P2X₃^−/− mice.

(a) Ultrasonographic findings of voiding in WT, P2X₂^−/− and P2X₃^−/− mice after LPS instillation. Images were obtained from the same mice after Fig. 2 recording. Scale bar, 5 mm. (b) Representative cystometrogram recording charts before and after LPS instillation. Scale bar, 10 min. (c–e) LPS-induced changes of pre-voiding largest CSA (c), post-voiding smallest CSA (d) and ICIs (e). *P < 0.05 (paired t-test with Holm correction), ^†P < 0.01 (time-by-group interaction by two-way repeated measures ANOVA with Holm correction) (n = 5, each group). Error bars represent s.e.m., n.s., not significant.