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. 2016 Jan 21;6:19552. doi: 10.1038/srep19552

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Copyright © 2016, Macmillan Publishers Limited

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(A) Relative frequencies of 96 trinucleotides are shown for cisplatin-treated and cisplatin-naïve SCCHN above and below, respectively. (B) The deciphered five mutational signatures are shown for their relative frequencies across 96 trinucleotides. Note that signature 1 (platinum) contributes to a substantial level of difference between cisplatin-treat and -naive SCCHN genomes in (A).