Table 1. Influences of IRF8/rs17445836 and IRF8/rs11642873 on BD risk.
| Stage | Genotype Allele | Case N (freq.) | Control N (freq.) | P value | Pc value | OR (95% CI) |
|---|---|---|---|---|---|---|
| rs17445836 | ||||||
| Stage I | A A | 2(0.005) | 1(0.002) | 0.353 | NS | 2.963(0.268–32.794) |
| A G | 31(0.081) | 85(0.151) | 0.001 | 0.039 | 0.498(0.323–0.768) | |
| G G | 349(0.914) | 478(0.848) | 0.003 | NS | 1.903(1.245–2.909) | |
| G | 729(0.954) | 1041(0.923) | 0.007 | NS | 1.741(1.163–2.606) | |
| A | 35(0.046) | 87(0.077) | 0.007 | NS | 0.574(0.384–0.860) | |
| Stage II | A A | 2(0.003) | 10(0.007) | 0.257 | NS | 0.426(0.093–1.949) |
| A G | 62(0.089) | 249(0.167) | 1.08 × 10−6 | 4.21 × 10−5 | 0.487(0.363–0.653) | |
| G G | 633(0.908) | 1231(0.826) | 4.74 × 10−7 | 1.85 × 10−5 | 2.081(1.557–2.781) | |
| G | 1328(0.953) | 2711(0.910) | 6.56 × 10−7 | 8.53 × 10−6 | 1.997(1.513–2.634) | |
| A | 66(0.047) | 269(0.090) | 6.56 × 10−7 | 8.53 × 10−6 | 0.501(0.380–0.661) | |
| Combined | A A | 4(0.004) | 11(0.005) | 0.525 | NS | 0.691(0.220–2.175) |
| A G | 93(0.086) | 334(0.163) | 3.14 × 10−9 | 1.22 × 10−7 | 0.486(0.381–0.619) | |
| G G | 982(0.910) | 1709(0.832) | 2.45 × 10−9 | 9.56 × 10−8 | 2.044(1.610–2.594) | |
| G | 2057(0.953) | 3752(0.913) | 8.14 × 10−9 | 1.06 × 10−7 | 1.932(1.539–2.426) | |
| A | 101(0.047) | 356(0.087) | 8.14 × 10−9 | 1.06 × 10−7 | 0.517(0.412–0.650) | |
| rs11642873 | ||||||
| Stage I | A A | 335(0.875) | 433(0.758) | 8.72 × 10−6 | 3.40 × 10−4 | 2.224(1.555–3.182) |
| A C | 48(0.125) | 133(0.233) | 3.25 × 10−5 | 1.27 × 10−3 | 0.472(0.329–0.676) | |
| C C | 0 | 5(0.009) | 0.066 | NS | 1.009(1.001–1.017) | |
| A | 718(0.937) | 999(0.875) | 8.09 × 10−6 | 1.05 × 10−4 | 2.141(1.532–3.010) | |
| C | 48(0.063) | 143(0.125) | 8.09 × 10−6 | 1.05 × 10−4 | 0.467(0.332–0.657) | |
| Stage II | A A | 590(0.858) | 1166(0.783) | 4.30 × 10−5 | 1.68 × 10−3 | 1.668(1.303–2.135) |
| A C | 92(0.134) | 307(0.206) | 4.85 × 10−5 | 1.89 × 10−3 | 0.594(0.462–0.765) | |
| C C | 6(0.009) | 16(0.011) | 0.661 | NS | 0.810(0.316–2.079) | |
| A | 1272(0.924) | 2639(0.886) | 1.04 × 10−4 | 1.35 × 10−3 | 1.571(1.249–1.977) | |
| C | 104(0.076) | 339(0.114) | 1.04 × 10−4 | 1.35 × 10−3 | 0.636(0.506–0.801) | |
| Combined | A A | 925(0.864) | 1609(0.781) | 2.37 × 10−8 | 9.24 × 10−7 | 1.776(1.449–2.176) |
| A C | 140(0.131) | 430(0.209) | 8.01 × 10−8 | 3.12 × 10−6 | 0.570(0.463–0.701) | |
| C C | 6(0.006) | 21(0.010) | 0.187 | NS | 0.547(0.220–1.359) | |
| A | 1990(0.929) | 3648(0.885) | 4.64 × 10−8 | 6.03 × 10−7 | 1.694(1.400–2.050) | |
| C | 152(0.071) | 472(0.115) | 4.64 × 10−8 | 6.03 × 10−7 | 0.590(0.488–0.714) | |
Pc: Bonferroni corrected p value, multiplied by 39/genotype and 13/allele. NS, not significant.