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Clinical photograph demonstrating cutaneous patch testing on the upper back of a female patient who has persistent pain, synovitis, and stiffness after a total knee arthroplasty with an implant of a cobalt-chromium alloy. A mild allergic reaction to nickel, consisting of erythema and edema, is shown in the upper left box. (Courtesy of Audrey Echt, MD, Raleigh, NC.)
