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. 2016 Jan 25;12(1):e1005815. doi: 10.1371/journal.pgen.1005815

Fig 7. Model for the role of Socs36E in CySCs.

Fig 7

Upd is produced by hub cells (green) and activates Stat92E (pSTAT) in CySCs (blue). JAK/STAT signaling upregulates the expression of Socs36E, which negatively regulates both JAK/STAT and MAPK signaling. pSTAT in CySCs primarily controls self-renewal (bigger arrow) but may also impact competition (smaller arrow). Spi is produced by GSCs/germ cells (red) and results in the activation of MAPK (pMAPK), which primarily regulates competitive behavior (bigger arrow) of CySCs but may also impact self-renewal (smaller arrow). In the absence of Socs36E, both JAK/STAT and MAPK pathways have elevated activity, resulting in increased self-renewal and increased competition.