Table 1. The rank order of fitnesses changes as a function of drug concentration.

Here we observe how the rank order of the fitnesses of alleles across the landscape changes as a function of drug environment. This dynamic order implies that the probability of individual trajectories must also change as a function of drug. Alleles that are in bold correspond to those that have been consistently observed in field isolates of P. falciparum (See Supporting Information for more references). Also note differences between the rank order patterns of PYR and CYC. Columns with a 16 in parentheses indicate that the allele is actually tied for the lowest ranking of all alleles in the set for that environment.

	Pyrimethamine concentration (uM)
Allele	0	10−3	10−2	10−1	1.0	10	102	103	104	105
0000	2	3	6	13	15	15	15	15	12(16)	8 (16)
0001	8	8	9	11	12	12	12	10	12 (16)	8 (16)
0010	11	11	11	5	6	6	6	6	6	7
0011	16	16	16	16	16	16	16	16	12 (16)	8 (16)
0100	4	5	4	9	14	14	14	10	12 (16)	8 (16)
0101	4	4	3	7	9	10	10	10	8	8 (16)
0110	2	2	2	2	2	2	3	4	4	2
0111	12	12	11	5	5	4	4	3	3	2
1000	14	14	14	14	13	13	12	10	12 (16)	8 (16)
1001	13	13	13	12	9	8	8	8	8	8 (16)
1010	6	6	4	3	3	5	5	5	5	5
1011	15	15	15	14	7	7	7	7	7	6
1100	8	8	9	10	11	11	11	10	8	8 (16)
1101	7	7	8	8	8	9	9	8	8	8 (16)
1110	1	1	1	1	1	1	1	2	2	2
1111	10	10	7	4	4	3	2	1	1	1
	Cycloguanil concentration (uM)
Allele	0	10 −3	10 −2	10 −1	1.0	10	10 2	10 3	10 4	10 5
0000	2	3	9	14	13	14	15	11	8 (16)	8 (16)
0001	8	8	9	8	9	10	9	8	8 (16)	8 (16)
0010	11	11	11	6	7	7	7	7	7	8 (16)
0011	16	16	16	16	14	16	16	16	8 (16)	8 (16)
0100	4	5	6	12	12	13	13	11	8 (16)	8 (16)
0101	4	3	4	9	10	12	11	11	8 (16)	8 (16)
0110	2	2	2	2	1	1	3	3	3	3
0111	12	11	6	5	4	1	1	1	1	1
1000	14	14	14	12	11	11	11	11	8 (16)	8 (16)
1001	13	13	12	10	8	8	8	8	8 (16)	8 (16)
1010	6	6	3	4	5	6	6	6	6	8 (16)
1011	15	15	15	11	6	5	4	4	4	3
1100	8	10	13	15	13	14	13	11	8 (16)	8 (16)
1101	7	7	6	7	9	9	9	8	8 (16)	8 (16)
1110	1	1	1	1	2	4	5	5	5	5
1111	10	9	5	3	3	3	2	2	2	2