| Glutamate excitotoxicity |
11 |
SLC1A2, GRIA1, GRIA2, GRIA3, GRIA4, SOD1, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D |
| Protein misfolding and aggregation |
23 |
SOD1, RNF19A, DERL1, MAP3K5, TARDBP, VCP, CSE1L, GRN, KPNA2, FUS, TNPO1, OPTN, NEFH, PRPH, FIG4, BICD2, ALS2, MTOR, SQSTM1, VAPB, CHMP2B, HSPA1A, HSPA1B |
| Mitochondrial dysfunction |
17 |
SOD1, KIF5B, MAPK11, MAPK11, MAPK12, MAPK13, MAPK14, DCTN1, KIFAP3, BCL2, Bcl-xL, XIAP, BAD, BAX, cytochrome c, caspase-3, caspase-9, ANG |
| Oxidative Stress |
6 |
SOD1, RAC1, NOX1, ERO1L, P4HB, PDIA3 |
| Defective RNA processing |
9 |
ANG, ELP3, FUS, FUS, SETX, SMN1, TARDBP, RGNEF, ATXN2, C9orf72 |
| Glial activation |
15 |
SLC1A2, SOD1, VEGFA, VEGFA, VEGFB, TNF, IL1B, CHGA, CHGB, SCG2, CD14, TLR2, IL4, IGF1, CX3CR1, CX3CL1 |
| Total number of seeds |
81 |
|
| Unique seeds |
72 |
|
