Table 2. The correlation between somatic KCNJ5 mutational status and preoperative clinical and biochemical parameters.
| Variable | KCNJ5 wild-type APA (n = 19) | KCNJ5 mutated APA (n = 47) | P | Adjusted P* |
|---|---|---|---|---|
| Age at diagnosis (years) | 48.5 ± 9.6 | 46.6 ± 12.7 | 0.562 | - |
| Age at diagnosis <35 years, n (%) | 0 (0.0) | 9 (19.1) | 0.040 | - |
| Female, n (%) | 7 (36.8) | 31 (66.0) | 0.030 | - |
| Body mass index (kg/m2) | 26.2 ± 3.4 | 23.6 ± 3.3 | 0.007 | - |
| SBP (mmHg) | 152 ± 13 | 145 ± 18 | 0.150 | 0.264 |
| DBP (mmHg) | 95 ± 8 | 93 ± 15 | 0.632 | 0.844 |
| Preoperative number of anti-hypertensive medications | 3 (1, 4) | 2 (1, 3) | 0.105 | 0.389 |
| Glomerular filtration rate (mL/min/1.73m2) | 80.0 ± 23.4 | 89.3 ± 28.3 | 0.221 | 0.821 |
| Preoperative lowest serum potassium level (mmol/L) | 2.9 (2.6, 3.0) | 2.8 (2.5, 3.1) | 0.842 | 0.877 |
| Preoperative PAC (ng/dL) | 48.2 (33.0, 55.2) | 41.3 (31.7, 52.5) | 0.395 | 0.607 |
| Preoperative PRA (ng/mL·hr) | 0.10 (0.10, 0.10) | 0.10 (0.10, 0.19) | 0.352 | 0.358 |
| Preoperative ARR (ng/dL)/(ng/mL·hr) | 432 (271, 536) | 358 (182, 489) | 0.315 | 0.407 |
| Lateralization index at adrenal vein sampling | 16.6 (5.2, 25.2) | 21.4 (9.4, 38.7) | 0.169 | 0.249 |
| Largest tumor size (cm) | 1.8 (1.2, 2.1) | 1.5 (1.2, 2.0) | 0.793 | 0.462 |
Data are presented as mean ± SD, median (25th, 75th), or n (%).
SBP, systolic blood pressure; DBP, diastolic blood pressure; PAC, plasma aldosterone concentration; PRA, plasma renin activity; ARR, aldosterone to renin ratio.
* P values were calculated after adjusting for age, gender, and body mass index.