Table 3.
Univariate analysis of risk factors for new-onset diabetes mellitus after liver transplantation
| Clinical factor | HR | 95%CI | P value |
| Recipient characteristics | |||
| Elder recipient (age > 50 yr) | 1.568 | 1.096-2.245 | 0.014 |
| Male recipient gender | 0.690 | 0.414-1.150 | 0.155 |
| Child-Pugh (A/B/C) | 0.985 | 0.788-1.232 | 0.895 |
| MELD Score | 1.107 | 0.997-1.037 | 0.088 |
| BMI ≥ 25 pre-LT | 1.616 | 1.100-2.373 | 0.014 |
| Hypertension pre-LT | 4.458 | 2.058-9.659 | < 0.001 |
| Dyslipidaemia pre-LT | 2.064 | 1.201-3.549 | 0.009 |
| Hepatitis B virus disease | 0.955 | 0.632-1.443 | 0.828 |
| Hepatitis C virus disease | 0.699 | 0.098-5.007 | 0.722 |
| Alcoholic cirrhosis | 2.307 | 1.076-4.948 | 0.032 |
| Tumors | 0.961 | 0.676-1.304 | 0.822 |
| With Rapamycin | 1.168 | 0.744-1.761 | 0.459 |
| With MMF | 0.979 | 0.690-1.387 | 0.903 |
| High mean cTAC (cTAC ≥ 5.89 ng/mL) | 8.709 | 5.873-12.915 | < 0.001 |
| BMI ≥ 25 post-LT | 1.345 | 0.927-1.951 | 0.119 |
| Hypertension post-LT | 1.278 | 0.808-2.021 | 0.294 |
| Dyslipidaemia post-LT | 2.014 | 1.429-2.838 | < 0.001 |
| CKD post-LT | 1.140 | 0.925-1.405 | 0.218 |
| AR post-LT | 1.701 | 1.056-2.742 | 0.029 |
| CR post-LT | 2.068 | 1.050-4.074 | 0.036 |
| Donor characteristics | |||
| Donor age at LT (per year) | 0.994 | 0.975-1.015 | 0.590 |
| Male donor gender | 1.202 | 0.766-1.886 | 0.423 |
| Donor type (LDLT) | 0.859 | 0.581-1.270 | 0.446 |
LT: Liver transplantation; MELD: Model for end-stage liver disease; MMF: Mycophenolate mofetil; cTAC: Tacrolimus trough concentration; CKD: Chronic kidney disease; AR: Acute rejection; CR: Chronic rejection; BMI: Body mass index; LDLT: Living donor liver transplantation.