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Global BOLD signal during an average of four Valsalva challenges averaged over 59 healthy subjects (18 s duration, target pressure 30 mmHg, starting at time 18 s). Mean of expiratory pressures in bottom graph. All subjects achieved target pressure for all four challenges. Blue overlays on average anatomical background indicate locations from which global BOLD signal was calculated (Data from Macey et al., 2014).
