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. 2016 Jan 26;8:90. doi: 10.3389/fnmol.2015.00090

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Copyright © 2016 Todkar, Granholm, Aljumah, Nilsson, Comasco and Nylander.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Relative gene expression (median) in animal facility reared rats. Between-group comparisons indicate an effect of voluntary ethanol drinking on (C) Crh in the hypothalamus (U = 20; p = 0.043) and (A) Crhr1 (U = 17; p = 0.012) in the pituitary and an effect of single housing on (A) Crhr1 (U = 14; p = 0.036) and (B) Pomc (U = 14; p = 0.036) in the pituitary. AU, arbitrary units; Crh, corticotropin releasing hormone; Crhr1, corticotropin releasing hormone receptor 1; E, ethanol drinking; g, group housed; Pomc, proopiomelanocortin; s, single housed; W, water drinking.^#p ≤ 0.05: effect of single housing; ^∗p ≤ 0.05: effect of ethanol.