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. 2016 Jan 26;8:90. doi: 10.3389/fnmol.2015.00090

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Copyright © 2016 Todkar, Granholm, Aljumah, Nilsson, Comasco and Nylander.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Relative gene expression in the MS rats. The two way ANOVA type III sum of squares test revealed a main effect of ELS on (A) Pomc in the hypothalamus (F = 5.806; p = 0.020; Adj. R² = 0.060) and (B) Dnmt1 in the pituitary (F = 10.316; p = 0.002; Adj. R² = 0.175). A main effect of ethanol (E) was found on (C) Crh in the hypothalamus (F = 4.092; p = 0.049; Adj. R² = 0.026), and (D) Fkbp5 in the pituitary (F = 4.495; p = 0.039; Adj. R² = 0.039). Crh, Corticotropin releasing hormone; Dnmt1, DNA methyltransferase (cytosine-5) 1; E, ethanol; ELS, early life stress; Fkbp5, FK506 binding protein 5; MS, maternal separation for 15/360 min; Pomc, proopiomelanocortin.