. 2016 Jan 25;11(1):e0145894. doi: 10.1371/journal.pone.0145894

Table 2. Plasma Phenylalanine (PHE) and Tyrosine (TYR) Concentrations (μmol/l).

Plasma Amino Acids	AN REC (n = 13)	HC (n = 12)	ANOVA ME Group	ANOVA ME Time	ANOVA ME Drink	ANOVA Group x Time	ANOVA Group x Drink	ANOVA Time x Drink	ANOVA Group x Time x Drink
PHE BAL PRE	53.69 ± 6.63	53.17 ± 5.31
PHE BAL POST	162.62 ± 55.44	128.75 ± 50.45
PHE APTD PRE	51.69 ± 5.19	53.33 ± 5.65
PHE APTD POST	11.15 ± 5.44	10.17 ± 4.02	F(1)=2.29, p=0.14, η²=0.09	^**F(1)=162.80, p<0.01, η²=0.88	^**F(1)=23.57, p<0.01, η²=0.51	F(1)=2.71, p=0.11, η²=0.11	F(1)=3.00, p=0.10, η²=0.12	^**F(1)=149.0, p<0.01, η²=0.87	F(1)=1.95, p=0.18, η²=0.08
TYR BAL PRE	49.39 ± 10.79	47.25 ± 7.03
TYR BAL POST	127.08 ± 26.12	117.25 ± 38.03
TYR APTD PRE	48.69 ± 7.98	50.83 ± 9.50
TYR APTD POST	13.08 ± 3.09	13.42 ± 3.58	F(1)=0.29, p=0.59, η²=0.01	^**F(1)=283.79, p<0.01, η²=0.93	^**F(1)=50.78, p<0.01, η²=0.69	F(1)=1.28, p=0.27, η²=0.05	F(1)=0.82, p=0.37, η²=0.03	^**F(1)=242.03, p < 0.01, η²=0.91	F(1)=0.17, p=0.68, η²=0.17

Legend: Plasma PHE and TYR concentrations observed at baseline (PRE) and 4 hours post amino acid drink consumption (POST). Results are reported for both the balanced (BAL) and the acute phenylalanine/tyrosine depletion (APTD) conditions. Data are expressed as Means ± SD. APTD resulted in a significant lowering of plasma PHE and TYR concentrations.

** P < 0.01.

AN REC: anorexia nervosa recovered. ANOVA: analysis of variance. HC: healthy controls. ME: main effect. SD: standard deviation. X: interaction effect.