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. 2015 Nov 10;11(1):191–196. doi: 10.3892/etm.2015.2847

Figure 4.

Figure 4.

Expression of the mfat-1 gene induced caspase-3-mediated cell apoptosis and inhibited GSK-3β phosphorylation in the Tca8113 cells. Expression of mfat-1 gene induced caspase-3 and caspase-9 cleavage, and reduced Tca8113 cell proliferation through reduction of GSK3β phosphorylation and subsequent downregulation of β-catenin expression. Caspase-3, caspase-9, GSK-3β, p-GSK-3β, β-catenin, p-Akt and Akt protein levels were examined by western blot. β-actin served as an equal loading control.