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. 2015 Nov 10;11(1):449–457. doi: 10.3892/ol.2015.3897

Figure 4.

Figure 4.

Inhibition of NF-κB activation by PDTC abrogates the effect of H. pylori-infected MSCs on gastric cancer cells. (A) The ability of H. pylori-infected MSCs to induce migration following pretreatment with PDTC was evaluated using cell culture inserts; magnification, ×100. (B) Histogram indicating the number of migrated SGC-7901 cells. Data are expressed as the mean ± standard deviation; *P<0.05 and **P<0.01. Data are representative of three independent experiments. (C) Capacity of cells to migrate to fill a scratched area devoid of cells was assessed in co-cultures of SCG-7901 cells with supernatants from (a) hucMSCs, (b) H. pylori-infected hucMSCs and (c) H. pylori-infected hucMSCs pretreated with PDTC for 48 h, respectively. (D) Western blot analyses of E-cadherin, N-cadherin and vimentin protein levels in SGC-7901 cells treated with the supernatants from hucMSCs, H. pylori-infected hucMSCs and the infected hucMSCs pretreated with PDTC, respectively. H. pylori, Helicobacter pylori; hucMSCs, human umbilical cord mesenchymal stem cells, PDTC, pyrrolidine dithiocarbamate; NF-κB, nuclear factor-κB.