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. 2016 Feb;89(2):287–296. doi: 10.1124/mol.115.101592

Fig. 5.

Fig. 5.

Antitumor effects of NT-7-16. (A) The effects of NT-7-16 on MDA-MB-435 tumors were evaluated in nude mice. The graph shows the average tumor volume ± S.D. starting on day 0. After the tumors were established, mice were treated daily by i.p. injection of 75 mg/kg NT-7-16. Paclitaxel was dosed at 20 mg/kg twice weekly. (B) Individual tumor volumes on day 14 are presented; the mean is represented by the horizontal line in each panel ± 95% confidence intervals. Statistical analysis was performed using a one-way ANOVA with a Tukey’s post hoc test to compare each condition with every other condition. A significant difference (P = 0.0018) was only found between the control and NT-7-16 groups. (C) Average percent weight change for each treatment group over the course of the trial ± S.D. Statistical analysis was performed using a one-way ANOVA with a Dunnet’s post hoc test to compare each drug treated condition to the control. A significant difference (P = 0.0014) was only found between the control and NT-7-16 groups.