Table I.
Patient characteristics according to the expression of ERCC1, BRCA1, RRM1 and TUBB3.
| ERCC1 expression | BRCA1 expression | RRM1 expression | TUBB3 expression | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Characteristics | Total, n (%) | − | + | P-value | − | + | P-value | − | + | P-value | − | + | P-value |
| NSCLC patients | 84 (100) | 38 | 46 | 73 | 11 | 11 | 73 | 8 | 76 | ||||
| Gender | |||||||||||||
| Female | 27 (32) | 12 | 15 | 0.92 | 23 | 4 | 1.00 | 4 | 23 | 1.00 | 3 | 24 | 1.00 |
| Male | 57 (68) | 26 | 31 | 50 | 7 | 7 | 50 | 5 | 52 | ||||
| Age | |||||||||||||
| ≤60 | 66 (79) | 33 | 33 | 0.09 | 56 | 10 | 0.50 | 8 | 58 | 0.91 | 6 | 60 | 1.00 |
| >60 | 18 (21) | 5 | 13 | 17 | 1 | 3 | 15 | 2 | 16 | ||||
| Smoking status | |||||||||||||
| Smoker | 52 (62) | 22 | 30 | 0.49 | 44 | 8 | 0.65 | 7 | 45 | 1.00 | 5 | 47 | 1.00 |
| Non-smoker | 32 (38) | 16 | 16 | 29 | 3 | 4 | 28 | 3 | 29 | ||||
| Alcohol Intake | |||||||||||||
| Yes | 6 (7) | 2 | 4 | 0.86 | 6 | 0 | 1.00a | 0 | 6 | 1.00a | 0 | 6 | 1.00a |
| No | 78 (93) | 36 | 42 | 67 | 11 | 11 | 67 | 8 | 70 | ||||
| Histology | |||||||||||||
| Adenocarcinoma | 53 (63) | 23 | 30 | 0.67 | 45 | 8 | 0.76 | 8 | 45 | 0.76 | 2 | 51 | 0.03 |
| Squamous cell carcinoma | 22 (26) | 12 | 10 | 20 | 2 | 2 | 20 | 3 | 19 | ||||
| Others | 9 (11) | 4 | 5 | 8 | 1 | 1 | 8 | 3 | 6 | ||||
| Stage | |||||||||||||
| II | 36 (43) | 16 | 20 | 0.90 | 34 | 2 | 0.15 | 6 | 30 | 0.60 | 4 | 32 | 1.00 |
| IIIa | 48 (57) | 22 | 26 | 39 | 9 | 6 | 42 | 4 | 41 | ||||
P-values were calculated using Pearson's χ2 test.
a
Calculated using Fisher's exact probablility. -, no expression; +, expression; NSCLC, non-small cell lung cancer; ERCC1, excision repair cross-complementation group 1; BRCA1, breast cancer 1; RRM1 ribonucleotide reductase M1; TUBB3, class III β-tubulin.