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. 2016 Feb;356(2):260–266. doi: 10.1124/jpet.115.229278

TABLE 2.

PK parameters after single doses of LY2456302


aGeometric Mean (Geometric %COV)
0.5 mg (n = 2) 2 mg (n = 4) 4 mg (n = 2) 10 mg (n = 4) 25 mg (n = 1)
Cmax (ng/ml) 0.53–0.90 4.20 (71%) 4.21–5.63 12.6 (61%) 15.2
btmax (h) 1.00–2.55 2.50 (1.00–4.00) 1.00–4.00 2.50 (2.50–4.00) 4.07
AUC (0–tlast) (ng ∣ h / ml) 2.42–3.66 28.4 (45%) 39.5–62.1 112 (45%) 154
a

The range for all parameters is reported where n = 2. Individual parameter is reported where n = 1.

b

Median (range).