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PK-RO Parameter Estimates
| Parameter | Mean Estimates (%rSE) | Intersubject Variability (%rSE) | 95% Confidence Interval |
|
|---|---|---|---|---|
| Lower | Upper | |||
| NLLS model (1-parameter) | ||||
| IC50 (ng/ml) | 0.83 (12) | 0.63 | 1.03 | |
| NLLS model (2-parameter) | ||||
| rmax (%) | 92.9 (4.9) | 83.4 | 102 | |
| IC50 (ng/ml) | 0.65 (20) | 0.37 | 0.92 | |
| Nonlinear mixed effect (NLME) | ||||
| rmax (%) | 92.8 (4.7) | 85.5 | 101 | |
| IC50 (ng/ml) | 0.58 (25) | 29.4% (150) | 0.38 | 0.85 |
rmax, maximum receptor occupancy; %rSE, relative standard error.
