Table II.

Top two enriched GO biological process term clusters with the highest enrichment score for the downregulated differentially-expressed genes.

Enrichment score	Term	Description	Count	P-value	Genes
4.727	GO:0006811	Ion transport	16	6.05×10−7	KCND3, GABRA1, GABRA4, GABRB2, GABRB1, CACNG6, ATP2B4, KCNT2, KCNH7, CACNA1A……
	GO:0030001	Metal ion transport	12	3.87×10−6	KCNJ5, KCND3, KCNJ6, ATP2B4, CACNG6, KCNH7, KCNH8, SCNN1G, KCNJ3, CACNA1A……
	GO:0006812	Cation transport	12	2.54×10−5	KCNJ5, KCND3, KCNJ6, ATP2B4, CACNG6, KCNH7, KCNH8, SCNN1G, KCNJ3, CACNA1A……
	GO:0006813	Potassium ion transport	7	7.01×10−5	KCNJ5, KCND3, KCNJ6, KCNT2, KCNH7, KCNH8, KCNJ3
	GO:0015672	Monovalent inorganic cation transport	8	5.52×10−4	KCNJ5, KCND3, KCNJ6, KCNT2, KCNH7, KCNH8, SCNN1G, KCNJ3
2.321	GO:0040018	Positive regulation of multicellular organism growth	4	2.47×10−4	GH1, DRD2, POU1F1, GHRHR
	GO:0021983	Pituitary gland development	4	5.70×10−4	DRD2, POU1F1, GHRHR, TBX19
	GO:0021984	Adenohypophysis development	3	8.52×10−4	DRD2, POU1F1, GHRHR
	GO:0021536	Diencephalon development	4	1.24×10−3	DRD2, POU1F1, GHRHR, TBX19
	GO:0043567	Regulation of insulin-like growth factor receptor signaling pathway	3	1.82×10−3	GH1, POU1F1, GHRHR
	GO:0040014	Regulation of multicellular organism growth	4	4.82×10−3	GH1, DRD2, POU1F1, GHRHR
	GO:0035270	Endocrine system development	4	6.09×10−3	DRD2, POU1F1, GHRHR, TBX19
	GO:0030900	Forebrain development	5	9.58×10−3	ERBB4, DRD2, POU1F1, GHRHR, TBX19
	GO:0045927	Positive regulation of growth	4	9.75×10−3	GH1, DRD2, POU1F1, GHRHR
	GO:0048732	Gland development	5	1.75×10−2	ERBB4, DRD2, POU1F1, GHRHR, TBX19
	GO:0045165	Cell fate commitment	4	3.22×10−2	NOTCH2, ERBB4, POU1F1, TBX19
	GO:0051240	Positive regulation of multicellular organismal process	5	3.49×10−2	GH1, ERBB4, DRD2, POU1F1, GHRHR
	GO:0042127	Regulation of cell proliferation	8	4.55×10−2	NOTCH2, ERBB4, DRD2, NR3C2, CDK6, POU1F1, GHRHR, TBX19

GO, gene ontology.