Table 1.
Presenting features of the studied patients
|
Treated group (n = 14) |
Untreated group (n = 9) |
|||
| Baseline | Post losartan | Baseline | Second biopsy | |
| Females/males | 4/14 | 1/8 | ||
| Age (yr) | 49.6±13 | |||
| Hematocrit | 45.2±3.59 | 44.1±3.85 | 48.8±4.66 | 47.8±4.15 |
| White blood cells (K/mm3) | 6.66±1.41 | 6.71±1.67 | 5.98±0.95 | 5.78±1.19 |
| Platelets (K/mm3 | 227±80.8 | 246±90.7b | 223±68 | 209±78.4 |
| Glucose (g/L) | 0.99±0.38 | 1±0.29 | 0.95±0.1 | 1.01±0.06 |
| Blood urea nitrogen (g/L) | 0.31±0.06 | 0.32±0.06 | 0.28±0.07 | 0.25±0.04 |
| Creatinine (mg/dL) | 0.88±0.07 | 0.95±0.11 | 0.99±0.07 | 0.96±0.12 |
| Total bilirubin (mg/dL) | 1±0.53 | 1.08±0.63 | 1.35±0.58 | 1.19±0.58 |
| Alkaline phosphatase (IU/L) | 253±118 | 269±68.9 | 264±93.4 | 349±134 |
| Alanine aminotransferase (IU/L) | 90.5±66 | 91.9±47.6 | 264±167a | 169±124 |
| Aspartate aminotransferase (IU/L) | 65.3±41 | 67±40.9 | 161±97.8a | 130±84.5 |
| Cholesterol (mg/dL) | 157±36.4 | 161±42.6 | 166±38.1 | 169±39.2 |
| Albumin (g/dL) | 4.12±0.32 | 4.43±0.24b | 4.32±0.56 | 4.32±0.5 |
| Globulins (g/dL) | 3.64±0.53 | 3.77±0.45 | 3.74±0.63 | 3.91±0.63 |
| G glutamyl transpeptidase (IU/ L) | 63.2±47.9 | 74.5±53.7 | 194±178a | 217±214 |
| Prothrombin time (%) | 103±19.3 | 106±17.4 | 107±8.19 | 97±9.83 |
| KPTT (s) | 32.6±3.38 | 39.6±18.7 | 37.8±6.99 | 34.5±2.38 |
Results are expressed as mean±SD.
a
P<0.05 in comparison with baseline measurements in the treated group.
b
P<0.01 in comparison with baseline measurements in the treated group.